Motoneurons of Spastic Stroke Survivors
نویسندگان
چکیده
Estimating the Time Course of Population Excitatory Postsynaptic Potentials in 1 Motoneurons of Spastic Stroke Survivors 2 Xiaogang Hu, PhD, Nina L. Suresh, PhD, and William Z. Rymer, MD, PhD 2 3 4 Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, Illinois 5 Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, 6 Northwestern University, Chicago, Illinois 7 8 Running Title: Prolonged EPSP Time Course in Stroke 9 10 Article type: Rapid Reports 11 12 Corresponding author: 13 Xiaogang Hu 14 Sensory Motor Performance Program 15 Rehabilitation Institute of Chicago 16 345 E Superior Street, Room 1406, Chicago, IL 60611 USA 17 Phone: 312-238-7199 18 Email: [email protected] 19 20 Articles in PresS. J Neurophysiol (December 24, 2014). doi:10.1152/jn.00946.2014
منابع مشابه
Sound-Evoked Biceps Myogenic Potentials Reflect Asymmetric Vestibular Drive to Spastic Muscles in Chronic Hemiparetic Stroke Survivors
Aberrant vestibular nuclear function is proposed to be a principle driver of limb muscle spasticity after stroke. We sought to determine whether altered cortical modulation of descending vestibulospinal pathways post-stroke could impact the excitability of biceps brachii motoneurons. Twelve chronic hemispheric stroke survivors aged 46-68 years were enrolled. Sound evoked biceps myogenic potenti...
متن کاملEstimating the time course of population excitatory postsynaptic potentials in motoneurons of spastic stroke survivors.
Hyperexcitable motoneurons are likely to contribute to muscle hypertonia after a stroke injury; however, the origins of this hyperexcitability are not clear. One possibility is that the effective duration of the Ia excitatory postsynaptic potential (EPSP) is prolonged, increasing the potential for temporal summation of EPSPs, making action potential initiation easier. Accordingly, the purpose o...
متن کاملOrigins of abnormal excitability in biceps brachii motoneurons of spastic-paretic stroke survivors.
Stroke survivors often exhibit abnormal motoneuron excitability, manifested clinically as spasticity with exaggerated stretch reflexes in resting muscles. We examined whether this abnormal excitability is a result of increased activation of intrinsic voltage-dependent persistent inward currents (PICs) or whether it is a result of enhanced synaptic inputs to the motoneuron. This distinction was ...
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30 Stroke survivors often exhibit abnormal motoneuron excitability, manifested clinically 31 as spasticity with exaggerated stretch reflexes in resting muscles. We examined whether this 32 abnormal excitability is a result of increased activation of intrinsic voltage-dependent 33 persistent inward currents (PICs), or whether it is due to enhanced synaptic inputs to the 34 motoneuron. This disti...
متن کاملOrigins of spontaneous firing of motor units in the spastic-paretic biceps brachii muscle of stroke survivors.
One potential expression of altered motoneuron excitability following a hemispheric stroke is the spontaneous unit firing (SUF) of motor units at rest. The elements contributing to this altered excitability could be spinal descending pathways, spinal interneuronal networks, afferent feedback, or intrinsic motoneuron properties. Our purpose was to examine the characteristics of spontaneous disch...
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